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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

This Protein May Strangle Tumors


Business Week (01/22/90) No. 3142, P. 78

Scientists at Repligen Corp. in Cambridge, Mass., have discovered a natural protein made by blood platelets, platelet factor 4, that blocks the formation of new blood vessels and can retard tumor growth. In animal tests, Repligen scientists showed that the protein inhibited tumor growth by preventing the tumors from forming networks of blood vessels necessary for growth and spread. The company plans to test a drug, Endostatin B, made by recombinant techniques from the active site of the protein this summer in AIDS patients with Kaposi's sarcoma. Kaposi's sarcoma is a cancer that involves rapid growth of endothelial cells, which line blood vessels.


Copyright © 1990 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in January 22, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.