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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

The Prognostic Value of Cellular and Serologic Markers in Infection with"


New England Journal of Medicine (01/18/90) Vol. 322, No. 3, P. 166

Progression to AIDS in HIV-infected patients is predicted most accurately by the level of CD4+ T lymphocytes in combination with the serum level of neopterin or beta-2-microglobulin, according to a study by John L. Fahey and colleagues of the UCLA Schools of Medicine and Public Health. In a four-year prospective study, the researchers monitored eight cellular and serologic markers of immune activation to evaluate the usefulness of these measures as indicators of the progression to AIDS in 395 HIV-positive men. The researchers report that the CD4+ T cell count expressed as an absolute number or as a ratio of CD4+ to CD8+ was the best single predictor; serum neopterin and beta-2-microglobulin levels had nearly as much predictive power. Fahey and colleagues recommend that at least one of these two serum markers, which reflect immune activation, be used with CD4+ count in disease classification and in the evaluation of response to therapy.


Copyright © 1990 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in January 18, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.