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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Major Study of People With HIV, TB is Set




 

Philadelphia Inquirer (04/06/93), P. A8 (Dixon, Jennifer)

The federal government yesterday revealed that it will launch the first major American study of drug treatment approaches for people infected with tuberculosis and HIV. Nearly 650 HIV -infected people with active TB will be involved in the clinical trials. Dr. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, said a substantial proportion of the subjects would probably be from New York City, where TB, particularly drug-resistant TB, is an increasing problem. In addition, the U.S. Department of Health and Human Services announced plans for a $2.1-million, five-year grant to Johns Hopkins University to examine the efficacy and appropriate use of AZT, DDI, and other anti-AIDS drugs. This move is a result of preliminary findings of the European Concorde study, which found that AZT is not effective when used in the early course of HIV infection. HHS Secretary Donna Shalala said, "While drugs have been reviewed for basic safety and effectiveness before they go on the market, these further studies should help physicians make the best treatment choices." The government will evaluate the clinical drug trials involving HIV-positive patients with TB for the benefit of adding a new drug for TB treatment, levofloxacin, to the usual four-drug therapy used in areas where TB organisms are commonly resistant to one or more anti-TB drugs. People who live in areas where drug-resistant TB is rare can also enroll in the trial and will receive the four-drug regimen without levofloxacin.



 


Copyright © 1993 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.



Information in this article was accurate in April 6, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.