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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Fat-Bubble Drugs Near Approval




 

Washington Post (Health) (07/04/95) P. 15

An advisory panel to the U.S. Food and Drug Administration has recommended approval of two experimental drugs made of fat bubbles for the treatment of Kaposi's sarcoma (KS). Scientists believe that the fat coating--made up of liposomes, or microscopic fat bubbles used to coat highly toxic medicines --allows the drugs to travel to site of the disease without spreading into other cells and poisoning them along the way. This method permits more of a drug to be delivered without severe side effects. The two drugs receiving tentative approval from the committee were NeXstar Pharmaceuticals Inc.'s DaunoXome and Liposome Technology Inc.'s Dox-SL, which was recommended under certain conditions. A study of more than 200 advanced KS patients found that those who received DaunoXome lived one year, while those on standard therapy lived 26 fewer days. More importantly, DaunoXome patients had 10 times fewer side effects than other patients, NeXstar officials said.



 


Copyright © 1995 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.



Information in this article was accurate in July 5, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.