Reuters Health Information Services (11/19/97)
New research published in the November 15 issue of AIDS
suggests that there is a high virological failure rate
associated with the use of HIV protease inhibitors.
Scientists from the University of Cologne in Germany report a
44 percent virological treatment failure rate in a study of
198 HIV-positive patients treated with protease inhibitors.
The findings suggest that the success seen in controlled
studies is not necessarily reflected in everyday practice, the
researchers noted. Further study, they said, should
investigate optimal initial therapy and optimal therapeutic
sequences for both untreated and pretreated individuals.