Science (06/04/99) No. 5420, Vol. 284, P. 1619
In an editorial, Neal Nathanson and Judith D. Auerbach, of the
Office of AIDS Research at the National Institutes of Health,
discuss NIH's new HIV prevention research program. The
program is a multidisciplinary approach, combining behavioral
science, social science, and biological methods, to fight the
spread of HIV. Researchers are prioritizing development of
microbicides for women, international prevention research,
interventions which are culturally and ethnically appropriate,
validation of prevention measures, and study of ethical
concerns regarding research and prevention programs. The new
research program is deemed of paramount importance because
AIDS has surpassed malaria and tuberculosis as the world's
leading infectious killer. Furthermore, prevention has proven
very effective, reducing annual incidence of HIV infection to
less 5 percent in some groups of gay men in the United States.
Needle-exchange programs have cut HIV transmission among
intravenous drug users by more than 30 percent in some places.
Behavioral strategies have cut infection rates by up to 50
percent in developing countries like Uganda, Thailand, and
Senegal, and blood screening technology has reduced the
transmission of HIV through bad blood by 99.9 percent in the
United States. The use of antiretroviral regimens has cut
perinatal transmission of HIV by up to 90 percent in optimal
settings. Successful behavioral strategies, as well as
cutting-edge biomedical technologies, are necessary to curb
the spread of HIV, the authors conclude.