Reuters Health Information Services (06/11/99)
In a report in the June 8th Proceedings of the National
Academy of Sciences, Dr. David M. Knipe and colleagues, from
Children's Hospital, Harvard Medical School, announced
progress in the development of a safe vaccine for genital
herpes. The vaccine is a mutant herpes simplex virus-2 (HSV-
2) strain, created by introducing two mutations into the HSV-2
genome. Animal studies have shown the vaccine to be safe and
effective, and researchers hope to begin clinical trials soon.
Knipe says that a vaccine that is defective for viral
replication and latent infection but that still produces
immunity may introduce a paradigm shift into viral sexually
transmitted disease vaccine research.