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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Double-Mutant HSV Vaccine Protects Animals Against Genital


Reuters Health Information Services (06/11/99)

In a report in the June 8th Proceedings of the National Academy of Sciences, Dr. David M. Knipe and colleagues, from Children's Hospital, Harvard Medical School, announced progress in the development of a safe vaccine for genital herpes. The vaccine is a mutant herpes simplex virus-2 (HSV- 2) strain, created by introducing two mutations into the HSV-2 genome. Animal studies have shown the vaccine to be safe and effective, and researchers hope to begin clinical trials soon. Knipe says that a vaccine that is defective for viral replication and latent infection but that still produces immunity may introduce a paradigm shift into viral sexually transmitted disease vaccine research.


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