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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Decline in Total Serum IgE After Treatment for Tuberculosis


Lancet (06/12/99) Vol. 353, No. 9169, P. 2030

South African researchers report "pronounced and consistent" reductions in levels of serum IgE, a marker of a type-2 immune response to intestinal parasites, following successful treatment of Mycobacterium tuberculosis, which produces a type-1 response. Type 1 and Type 2 responses inhibit each other. The prospective study, conducted in the Western Cape Province of South Africa, found that overall IgE levels were high in both the controls and patients prior to therapy. Concentrations declined in all patients after successful treatment. Members of the control group had lower ascaris- specific IgE than patients prior to treatment, and the level was 2.39 kU/L in patients following therapy. The findings suggest that human IgE concentrations could be downregulated in such situations, possibly by boosting a type-1 response.


Copyright © 1999 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in June 16, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.