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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Inhibition of HIV Replication by Dominant Negative Mutants of


Nature Medicine (06/99) Vol. 5, No. 6, P. 635

A study of Sam68 (Src-associated protein in mitosis) and a mutant Rev protein, RevM10, indicate potential methods for viral gene therapy. Investigators found that Sam68 specifically interacts with the Rev response element (RRE) and can partially replace and synergize with Rev in RRE-mediated gene expression and virus replication. According to the data, c-terminally deleted mutants of Sam68 blocked the transactivation of RRE-mediated expression by wild-type Sam68 and Rev. The mutants, which hampered the nuclear localization of Rev in co-expressed cells, stopped wild-type HIV-1 replication as well as the RevM10 mutant. The researchers suggest they may be useful in anti-AIDS treatments.


Copyright © 1999 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in June 21, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.