inhibition of hiv replication by dominant negative mutants of

CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update Inhibition of HIV Replication by Dominant Negative Mutants of Reddy, Thipparthi R.; Xu, Weidong; Mau, Jonathan K.L.; et
June 21, 1999

Nature Medicine (06/99) Vol. 5, No. 6, P. 635 A study of Sam68 (Src-associated protein in mitosis) and a mutant Rev protein, RevM10, indicate potential methods for viral gene therapy. Investigators found that Sam68 specifically interacts with the Rev response element (RRE) and can partially replace and synergize with Rev in RRE-mediated gene expression and virus replication. According to the data, c-terminally deleted mutants of Sam68 blocked the transactivation of RRE-mediated expression by wild-type Sam68 and Rev. The mutants, which hampered the nuclear localization of Rev in co-expressed cells, stopped wild-type HIV-1 replication as well as the RevM10 mutant. The researchers suggest they may be useful in anti-AIDS treatments.

Most Read: Latest Added Related Topics White House LGBT Conference on HIV/AIDS UNITED STATES: White House in Atlanta: LGBT AIDS Conference No more single-theme conferences: global HIV prevention conference planned FHI 360 Senior Scientist Lut Van Damme Receives International Microbicide Conference Lifetime Achievement Award Equatorial Guinea Ministry of Health and Social Welfare and UNICEF Refute Erroneous AIDS Prevalence Figures Photographs from A Day with HIV Now Online Bulgaria urges Libya to investigate AIDS nurses case Engineers enter fight against AIDS in Africa Gilead’s Complera® Non-Inferior to Atripla® Among Treatment-Naive HIV Patients UN chief Ban calls world leaders to end Aids by 2020 Positive living Lawyer: NY man at center of HIV scare not positive Zimbabwe activist: Prisoners denied AIDS drugs Youth organizations form a pact for social transformation in the AIDS response CountyCare Offers Historic Opportunity to Improve Care for People with HIV International AIDS Advocates Demand China Give $1 Billion to Global Fund Kingdom of Bahrain and UNAIDS commit to intensify cooperation CANADA: Celibate Homosexual Men Now Allowed to Donate Blood in Canada AFRICA: UN: AIDS Deaths Down, Treatment Up in Africa MICHIGAN: STD Fee for Jackson County Walk-In Clinic Takes Effect June 3 CountyCare Offers Historic Opportunity to Improve Care for People with HIV Lawyer: NY man at center of HIV scare not positive GLOBAL: HIV Outcomes Could Improve by Integrating Treatment of Comorbid Mental Illness UNITED STATES: How Sexual Stigma Is Undermining HIV Treatment on American Indian Reservations HHS Office for Civil Rights launches campaign to increase awareness of HIPAA rights among HIV-positive Black men Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog Living with HIV Global HIV/AIDS leaders meet in SF, Oakland Ugandan youth move to front line of HIV, maternal health fight OVER 7 MILLION PEOPLE NOW RECEIVING HIV TREATMENT IN AFRICA - UN REPORT
Copyright © 1999 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles. Information in this article was accurate in June 21, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.