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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

Measurement of Sputum Mycobacterium Tuberculosis Messenger RNA


American Journal of Respiratory and Critical Care Medicine

In an effort to identify surrogate markers for response to chemotherapy, researchers from the United States and Brazil measured levels of Mycobacterium tuberculosis 85B messenger RNA (mRNA), 16S ribosomal RNA, and IS6110DNA found in patients' sputa. According to the authors, the quick disappearance of M. tuberculosis mRNA from sputum indicates that it is a useful marker for rapid assessment of response to chemotherapy and a good indicator of microbial viability.


Copyright © 1999 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in July 26, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.