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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update

The Real Drug Problem: Forgetting to Take Them


Wall Street Journal (10.21.03) - Thursday, October 23, 2003

While much of the national debate is focused on how to help more people afford costly medicines, there is an increasingly urgent problem of non-adherence for patients already on drug therapies.

Earlier this year, the World Health Organization reported that only around 50 percent of people typically follow their doctors' orders when it comes to taking prescribed medicine. And the consequences of non-adherence are significant. Failure to take prescribed drugs contributes to everything from AIDS deaths to avoidable emergency room admissions, and it can undermine the management of chronic conditions.

This phenomenon helps to explain why the promising results of clinical trials are often unmatched when drugs are in the hands of patients. For instance, trials of antiretroviral therapies have proved effective in suppressing HIV in as many as 95 percent of participating patients. But in routine daily life, the reported rates of HIV suppression drop to the 40-50 percent range. Doctors believe the discrepancy is one important reason why there continue to be so many AIDS-related deaths.

The issue of non-adherence, even when the drugs may prolong or save patients' lives, belies simple explanation or demographics. Rich, highly educated people are just as likely not to take their drugs as poor or less-educated people. Complex regimens, forgetfulness and the increasing cost of drugs all contribute, but the major reason appears to be a fear of side effects. People dislike the way they feel when they take multiple drugs, so they simply stop taking them.

Later this year in Dallas, a second annual conference devoted exclusively to improving adherence to HIV therapies will be held. In addition, WHO is developing a training package for health care and community professionals focused on how to get patients to better adhere to antiretroviral therapy. And NIH currently has over 35 trials studying ways to improve patient adherence to medication for a range of conditions, including depression and other psychiatric disorders.


Copyright © 2003 -CDC Prevention News Update, Publisher. All rights reserved to Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

Information in this article was accurate in October 23, 2003. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.