Resource Logo
NLM AIDSLINE

Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.




 

FEBS Lett. 1999 Nov 26;462(1-2):140-4. Unique Identifier : AIDSLINE

We have previously shown that human immunodeficiency virus (HIV)-1-tat induces the production of matrix metalloproteinase-9 (MMP-9) in human monocytes by a mechanism that is not understood. In the present report, we demonstrate that HIV-tat-induced expression of MMP-9 is blocked by inhibitors of protein tyrosine phosphatases (PTPases). PTPase inhibitors also blocked HIV-tat-induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction. These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB.

JOURNAL ARTICLE DNA-Binding Proteins/METABOLISM Enzyme Induction Gelatinase B/*BIOSYNTHESIS Gene Products, tat/*PHARMACOLOGY Human HIV-1/METABOLISM Monocytes/ENZYMOLOGY/*VIROLOGY NF-kappa B/*METABOLISM Protein-Tyrosine-Phosphatase/ANTAGONISTS & INHIB/*METABOLISM Support, Non-U.S. Gov't U937 Cells



 




Information in this article was accurate in March 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.