FEBS Lett. 1999 Nov 26;462(1-2):140-4. Unique Identifier : AIDSLINE
We have previously shown that human immunodeficiency virus (HIV)-1-tat
induces the production of matrix metalloproteinase-9 (MMP-9) in human
monocytes by a mechanism that is not understood. In the present report,
we demonstrate that HIV-tat-induced expression of MMP-9 is blocked by
inhibitors of protein tyrosine phosphatases (PTPases). PTPase inhibitors
also blocked HIV-tat-induced nuclear transcription factor NF-kappaB
activation and IkappaBalpha degradation required for MMP-9 induction.
These results suggest that HIV-tat induces MMP-9 in human monocytes
through activation of PTPase and NF-kappaB.
JOURNAL ARTICLE DNA-Binding Proteins/METABOLISM Enzyme Induction
Gelatinase B/*BIOSYNTHESIS Gene Products, tat/*PHARMACOLOGY Human
HIV-1/METABOLISM Monocytes/ENZYMOLOGY/*VIROLOGY NF-kappa B/*METABOLISM
Protein-Tyrosine-Phosphatase/ANTAGONISTS & INHIB/*METABOLISM Support,
Non-U.S. Gov't U937 Cells