is1245 genotypic analysis of mycobacterium avium isolates from patients in brazil.

NLM AIDSLINE IS1245 genotypic analysis of Mycobacterium avium isolates from patients in Brazil. Saad MH; Fonseca LD; Ferrazoli L; Fandinho F; Palaci M; Grinsztejn B;
March 30, 2000

Int J Infect Dis. 1999 Summer;3(4):192-6. Unique Identifier : AIDSLINE OBJECTIVE: Disseminated Mycobacterium avium infection is an emerging opportunistic disease among patients with acquired immunodeficiency syndrome (AIDS) in Brazil. The mode of transmission of M. avium in a developing country setting needs to be better characterized. METHODS: Mycobacterium avium strain collections in Sao Paulo and Rio de Janeiro were analyzed according to the strains' IS1245 DNA gel electrophoretic migration patterns. Medical records of the patients from whom M. avium isolates were available were reviewed, and their demographic characteristics were stratified according to the isolates' IS1245 DNA fingerprint patterns. RESULTS: Of 105 patients, 33 (31%) with M. avium isolated between 1990 and 1994 had strains having IS1245 patterns identical in patterns seen in isolates from two or more patients (designated as cluster pattern strains). Cluster pattern strains were isolated from 21 (39%) of 54 patients with disseminated infection (defined as infection due to M. avium isolated from a sterile site in an adult patient). Six of the cluster pattern strains were isolated only from sterile sites. In Sao Paulo, cluster pattern strains were significantly more likely to be isolated from patients with disseminated disease. CONCLUSIONS: These preliminary observations suggest that in large cities of Brazil, a high proportion (at least 39%) of disseminated M. avium infections in patients with AIDS results from a recent transmission. Some strains of M. avium may be more likely to cause disseminated disease than others after an infection. JOURNAL ARTICLE Adolescence Adult AIDS-Related Opportunistic Infections/MICROBIOLOGY/TRANSMISSION Bacterial Typing Techniques Blood/MICROBIOLOGY Brazil/EPIDEMIOLOGY Child Child, Preschool DNA Fingerprinting DNA Transposable Elements Female Genotype Human Male Middle Age Mycobacterium avium Complex/CLASSIFICATION/GENETICS/ISOLATION & PURIF Mycobacterium avium-intracellulare Infection/MICROBIOLOGY/ TRANSMISSION Retrospective Studies Sputum/MICROBIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.

Most Read: Latest Added Related Topics White House LGBT Conference on HIV/AIDS UNITED STATES: White House in Atlanta: LGBT AIDS Conference No more single-theme conferences: global HIV prevention conference planned FHI 360 Senior Scientist Lut Van Damme Receives International Microbicide Conference Lifetime Achievement Award Photographs from A Day with HIV Now Online Equatorial Guinea Ministry of Health and Social Welfare and UNICEF Refute Erroneous AIDS Prevalence Figures Bulgaria urges Libya to investigate AIDS nurses case Engineers enter fight against AIDS in Africa Gilead’s Complera® Non-Inferior to Atripla® Among Treatment-Naive HIV Patients UN chief Ban calls world leaders to end Aids by 2020 ARIZONA: Routine Skin Testing Available Again at Tuberculosis Clinic Starting May 20 NORTH DAKOTA: Officials: 26 Tuberculosis Cases from Grand Forks Outbreak AUSTRALIA: HIV Rates Triple in the Northern Territory in Just 12 Months ARIZONA: Parsons Foundation Gives $3 Million to Southwest Center for HIV/AIDS UNITED STATES: Triple Therapy for Hepatitis C is Effective After Liver Transplantation, but Side-Effects Are Common CANADA: Nunavut Uses Comic Book to Do Sex Education NEW HAMPSHIRE: State Health Officials Urge Hepatitis Testing UNITED STATES: Hepatitis C Testing for People Born Between 1945 and 1965 People with HIV pay more for life insurance – if they can get it (South Africa)Uganda: Gov't Urged to Levy a Tax On Alcohol to Fund HIV Public Meeting on HIV Patient-Focused Drug Development and HIV Cure Research: June 14, 2013 Legal help for AIDS patients UNITED STATES: Pretreatment Anemia Raises Mortality Risk Among HCV/HIV Coinfected Patients Analysis: Sending the right message on mHealth New Research Uncovers Willful Misrepresentation of Medical Data in Creation of AIDS "Patient Zero" Myth GEORGIA: Director of AIDS Athens 'Inspired' from Helping Her Patients Analysis: The plight of LGBTI asylum seekers, refugees Okla. Health Dept. accounts for juvenile patients Sustiva (efavirenz) pediatric patients labeling update INTERNATIONAL: International News Compassionate Access to New Hepatitis C Drugs an 'Emergency' for European Patients
Information in this article was accurate in March 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.