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A new sulfated beta-galactan from clams with anti-HIV activity.


Carbohydr Res. 1999 Sep 15;321(1-2):121-7. Unique Identifier : AIDSLINE

A new polysaccharide composed of galactan sulfate with a beta-(1-->3)-glycosidic linkage has been isolated from the marine clam species Meretrix petechialis. The polysaccharide was homogeneous in its composition containing D-galactose. The glycosidic linkage was examined by 2D DQF-COSY and 2D NOESY spectroscopy. The coupling constant of anomeric proton was 7.8 Hz, suggesting a beta-galacto configuration. The downfield shift of H-2 of galactose residue demonstrated the presence of 2-O-sulfonate group. TQF-COSY confirmed that the C-6 position was substituted with a sulfonate group. The anti-HIV activity of the polysaccharides has been evaluated by the inhibition of syncytia formation. The fusion index and percentage fusion inhibition of sulfated galactan were 0.34 and 56% at 200 micrograms/mL.

JOURNAL ARTICLE Animal Anti-HIV Agents/*ISOLATION & PURIF Carbohydrate Sequence Clams/*CHEMISTRY Dextran Sulfate/PHARMACOLOGY Galactans/*ISOLATION & PURIF/PHARMACOLOGY Giant Cells/DRUG EFFECTS Hela Cells Human HIV-1/DRUG EFFECTS Membrane Fusion/DRUG EFFECTS Molecular Sequence Data Nuclear Magnetic Resonance Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.


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