Resource Logo

Immune response following fresh arterial homograft replacement for aortoiliac graft infection.


Eur J Vasc Endovasc Surg. 1999 Nov;18(5):424-9. Unique Identifier :

INTRODUCTION: this prospective study defines the immune response to fresh arterial homograft replacement for graft infection. MATERIALS AND METHODS: ten patients who underwent ABO-compatible homograft transplantation were studied for anti-HLA antibody production, and CD3-CD4-CD8-positive lymphocytes subset. Immunological studies were performed preoperatively, and at early (1, 3, 7 days) and late (1, 3, 6, 12, 18, 24 months) follow-up. All patients received immunosuppressive treatment with cyclosporine (1-3 mg/kg/day). Abdominal CT scans were performed postoperatively at the 1, 6, 12, 18, 24 months follow-up. RESULTS: preoperatively, antibodies could not be detected. Postoperatively, as from 1st month post-transplant, a progressive increase in % PRA was observed in all patients, up to the 12th month of follow-up. Subsequently, at 18 and 36 months, a progressive decrease in % PRA was detected. Data showed that the recipient antibodies were directed against donor-specific antigens. During the immediate postoperative period (1, 3, 7 days) CD3- and CD4-positive T lymphocytes slightly increased, whereas CD8 simultaneously decreased. Later, CD3 and CD4 progressively decreased and CD8 increased. Clinically, all patients were cured of infection at late follow-up. CT scans showed thickening of the aortic wall (range: 2.5-4.5 mm), with no signs of aneurysmal degeneration. CONCLUSIONS: fresh arterial homografts are immunogenic. Implanted homografts induce a strong anti-HLA antibody response, similar to chronic rejection, in spite of immunosuppressive treatment. Copyright 1999 Harcourt Publishers Ltd.

JOURNAL ARTICLE Aged Antibody Specificity/IMMUNOLOGY Antigens, CD3/IMMUNOLOGY Aorta, Abdominal/*SURGERY Arteries/IMMUNOLOGY/*TRANSPLANTATION ABO Blood-Group System/IMMUNOLOGY Blood Vessel Prosthesis/*ADVERSE EFFECTS Comparative Study CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Femoral Artery/SURGERY Human HLA Antigens/IMMUNOLOGY Iliac Artery/*SURGERY Male Middle Age Prospective Studies Prosthesis-Related Infections/*IMMUNOLOGY/SURGERY Reoperation Time Factors Transplantation Immunology/IMMUNOLOGY Transplantation, Homologous


Information in this article was accurate in March 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.