Ann Pharmacother. 2000 Jan;34(1):89-93. Unique Identifier : AIDSLINE
OBJECTIVE: To describe the role of hydroxyurea in the treatment of
HIV-1. DATA SOURCES: Published clinical studies using hydroxyurea in HIV
treatment were accessed through MEDLINE (January 1994-March 1999) and
conference abstracts. All relevant studies were evaluated. DATA
SYNTHESIS: Adherence, expense, and resistance limit the
pharmacotherapeutic options in the management of patients with HIV.
Hydroxyurea may be an alternative to conventional HIV treatments.
CONCLUSIONS: Several potential advantages of adding hydroxyurea to
antiretroviral treatment regimens include the drug's well-documented
toxicity, convenient dosing, good tolerability and low cost, and its
unique mechanism of action. Hydroxyurea may have synergistic effects
that prove promising in initial and salvage therapy antiretroviral
regimens. Larger, well-controlled clinical studies are needed to
adequately define the role of hydroxyurea in the treatment of HIV.
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Acquired Immunodeficiency
Syndrome/*DRUG THERAPY/VIROLOGY Human Hydroxyurea/*THERAPEUTIC USE
HIV Infections/*DRUG THERAPY/VIROLOGY *HIV-1 Nucleic Acid Synthesis