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Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones.




 

J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):1-7. Unique Identifier :

Neutralizing antibodies and specific cytotoxic T lymphocytes (CTL) may contribute to controlling viral spread, and ideally, to virus clearance in HIV infection. Both effector mechanisms depend on specific CD4 T-helper (Th) cells. Nevertheless, HIV hypervariability facilitates appearance of escape mutants for antibodies and for CTL responses. Here we also show that natural mutations (i.e., from sequences of different HIV strains) in an immunodominant Th epitope recognized by human CD4 clones specific for the envelope glycoprotein gp120 escape CD4 T-cell recognition. Furthermore, several natural analogue peptides exert an antagonistic function by inhibiting proliferative response of T cells specific to gp120 with a wild-type sequence. If similar events occur in vivo, they may represent an additional escape mechanism for HIV. In fact, antagonism for CD4 Th response may occur during superinfection with a different strain, or with the appearance of a variant carrying a mutated antagonistic sequence. In both cases, impaired Th cell function could lead to reduced immune control of HIV infection by interfering with CTL and antibody response.

JOURNAL ARTICLE Amino Acids/IMMUNOLOGY Clone Cells CD4-Positive T-Lymphocytes/*DRUG EFFECTS Epitopes Human HIV Envelope Protein gp120/GENETICS/*IMMUNOLOGY HIV-1/GENETICS/*IMMUNOLOGY Immunodominant Epitopes Mutation Oligopeptides/IMMUNOLOGY/*PHARMACOLOGY Support, Non-U.S. Gov't T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY



 




Information in this article was accurate in May 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.