Rinsho Ketsueki. 1999 Nov;40(11):1187-92. Unique Identifier : AIDSLINE
A 58-year-old man was referred to our hospital because of painful
swelling in the left lower leg and leukocytosis in January 1999.
Moderate hepatosplenomegaly but no lymph node swelling was observed.
Marked leukocytosis (leukocytes 44.9 x 10(4)/microliter with 95%
morphologically prolymphocytes) and thrombocytopenia were detected. The
surface phenotype of the leukemia cells was CD1-2+3+5+7+4+8+25+.
Magnetic resonance imaging revealed dilated veins in the left lower leg.
An abnormal 47XY, +22 karyotype was detected in 1/20 cells. Tests for
HTLV-I antibody were negative. A diagnosis of T-cell prolymphocytic
leukemia (T-PLL) was made on the basis of data including cytochemical
and electron microscopic findings. Although 2 courses of chemotherapy
comprising vincristine, cyclophosphamide, and prednisolone improved the
venous thrombosis in the leg, the leukemia cells were refractory to
chemotherapy. To prevent the recurrence of venous thrombosis due to
leukostasis, the patient underwent repeated leukapheresis. The leukocyte
count was maintained at around 20.0 x 10(4)/microliter after total 7
courses of leukapheresis, one course of which comprised 7l of
extracorporeal circulation. In addition to the rare presentation of
venous thrombosis, the CD4+8+25+ phenotype observed in this case is rare
in patients with T-PLL.
JOURNAL ARTICLE Case Report CD4-CD8 Ratio English Abstract Human
Leg Leukapheresis Leukemia, T-Cell/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY
Male Middle Age Phenotype Receptors, Interleukin-2 Venous