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NLM AIDSLINE

Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with triazole.




 

Arzneimittelforschung. 2000 Jan;50(1):55-9. Unique Identifier : AIDSLINE

Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4'-pyridyl)-4-amino-5-mercapto-4-(H)-1,2,4-triazole to form Schiff bases and the N-Mannich bases of these compounds were synthesised by reacting them with formaldehyde and several secondary amines. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. Investigation of antimicrobial activity of compounds was done by agar dilution method against 27 pathogenic bacteria, 8 pathogenic fungi and anti-HIV activity against replication of HIV-1 (III B) in MT-4 cells. Among the compounds tested 1-(piperidinomethyl) 5-bromo 3-[3'-(4"-pyridyl)-5'-mercapto-4'-(H)-1',2',4'-triazol 4'-yl]imino isatin showed the most favourable antimicrobial activity.

JOURNAL ARTICLE Anti-HIV Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Anti-Infective Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antifungal Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Bacteria/DRUG EFFECTS Cell Line Fungi/DRUG EFFECTS Isatin/*ANALOGS & DERIVATIVES/CHEMICAL SYNTHESIS/*PHARMACOLOGY Mannich Bases/CHEMICAL SYNTHESIS/*PHARMACOLOGY Microbial Sensitivity Tests Nuclear Magnetic Resonance Schiff Bases/CHEMICAL SYNTHESIS/*PHARMACOLOGY Spectrophotometry, Infrared Triazoles/*CHEMICAL SYNTHESIS/PHARMACOLOGY



 




Information in this article was accurate in June 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.