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Plasma HIV-1 RNA quantitation in HIV infected adult Zimbabweans.


Cent Afr J Med. 1999 Sep;45(9):231-4. Unique Identifier : AIDSLINE

OBJECTIVES: To determine HIV-1 RNA levels in plasma of HIV infected Zimbabwean adults and to correlate these with CD4+ cell counts. DESIGN: Prospective observational study. SETTING: Specialist Immunology Laboratory, Harare, Zimbabwe. SUBJECTS: 49 consecutive HIV infected patients. MAIN OUTCOME MEASURES: CD4+ cell counts and plasma HIV-1 RNA levels. RESULTS: Based on the CDC HIV classification system five patients were in early stage infection, 15 in middle, 17 in late and 12 in advanced stage of infection. The median CD4+ cell count was 165/microL (Q1 = 4; Q3 = 866). The median HIV-1 RNA levels were 73,097 RNA copies/ml (Q1 = 753; Q3 = 750,000). Eighty percent of the patients had HIV-1 RNA levels > 10,000 copies/ml and 49% had > 100,000 RNA copies/ml. Median viral loads among the four categories of infection were found to be highly significant (p < 0.001). The correlation between CD4+ cell counts and HIV-1 RNA copies for the 49 patients was highly significant (r = -0.76; p < 0.001). CONCLUSIONS: High treatment HIV-1 RNA levels were determined in the majority of patients. A highly significant correlation was obtained between plasma HIV-1 RNA levels and CD4+ cell counts.

JOURNAL ARTICLE Adult CD4 Lymphocyte Count Disease Progression Female Human HIV Infections/*BLOOD/CLASSIFICATION/IMMUNOLOGY/*VIROLOGY HIV-1/*GENETICS Male Middle Age Predictive Value of Tests Prospective Studies Regression Analysis Reproducibility of Results RNA, Viral/*BLOOD Severity of Illness Index *Viral Load Zimbabwe


Information in this article was accurate in December 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.