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Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy.




 

J Neuroimmunol. 2000 Sep 1;109(1):30-3. Unique Identifier : AIDSLINE

Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effectors, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma by T cells. Leukemia inhibitory factor (LIF), essential for embryo implantation, is up-regulated by IL-4 and progesterone. Moreover, the production of LIF and/or Th2 cytokines by decidual T cells contributes to the maintenance of pregnancy. Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy.

JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Cytokines/*PHYSIOLOGY Female Growth Inhibitors/PHYSIOLOGY Human Interleukin-10/PHYSIOLOGY Lymphokines/PHYSIOLOGY Pregnancy/*IMMUNOLOGY Progesterone/*PHYSIOLOGY Relaxin/*PHYSIOLOGY Th1 Cells/*PHYSIOLOGY Th2 Cells/*PHYSIOLOGY



 




Information in this article was accurate in December 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.