J Neuroimmunol. 2000 Sep 1;109(1):30-3. Unique Identifier : AIDSLINE
Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2
(Th2) effectors, as characterized by their opposite pattern of cytokine
production, can be influenced by several factors, including hormones.
Progesterone promotes the production of IL-4 and IL-5, whereas relaxin
promotes the production of IFN-gamma by T cells. Leukemia inhibitory
factor (LIF), essential for embryo implantation, is up-regulated by IL-4
and progesterone. Moreover, the production of LIF and/or Th2 cytokines
by decidual T cells contributes to the maintenance of pregnancy. Our
results suggest that relaxin and progesterone may contribute to the
regulation of the immune homeostasis during pregnancy.
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Cytokines/*PHYSIOLOGY Female
Growth Inhibitors/PHYSIOLOGY Human Interleukin-10/PHYSIOLOGY
Lymphokines/PHYSIOLOGY Pregnancy/*IMMUNOLOGY Progesterone/*PHYSIOLOGY
Relaxin/*PHYSIOLOGY Th1 Cells/*PHYSIOLOGY Th2 Cells/*PHYSIOLOGY