Unique Identifier : AIDSLINE MED/20300190
HIV-1 has been shown to infect CD4 negative cells by the binding of HIV
gp120 to the glycolipid galactosylceramide (1) (GalCer). Several
analogues of 1 were prepared to investigate the specific orientation of
1 in the membrane bilayer that is involved in gp120 binding.
Interestingly, N-stearyl-1-deoxynojirimycin (8) displayed potent and
specific affinity for gp120 equal to that of 1, a finding that may shed
light on the antiviral activity of N-butyl-1-deoxynojirimycin.
JOURNAL ARTICLE Anti-HIV Agents/CHEMICAL
Glycolipids/*CHEMICAL SYNTHESIS/*METABOLISM/PHARMACOLOGY HIV Envelope
Protein gp120/*METABOLISM Lipid Bilayers