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NLM AIDSLINE

Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.




 

Unique Identifier : AIDSLINE MED/20300190

HIV-1 has been shown to infect CD4 negative cells by the binding of HIV gp120 to the glycolipid galactosylceramide (1) (GalCer). Several analogues of 1 were prepared to investigate the specific orientation of 1 in the membrane bilayer that is involved in gp120 binding. Interestingly, N-stearyl-1-deoxynojirimycin (8) displayed potent and specific affinity for gp120 equal to that of 1, a finding that may shed light on the antiviral activity of N-butyl-1-deoxynojirimycin.

JOURNAL ARTICLE Anti-HIV Agents/CHEMICAL SYNTHESIS/METABOLISM/PHARMACOLOGY Galactosylceramides/*METABOLISM Glycolipids/*CHEMICAL SYNTHESIS/*METABOLISM/PHARMACOLOGY HIV Envelope Protein gp120/*METABOLISM Lipid Bilayers



 




Information in this article was accurate in December 30, 2000. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.