Virology. 1984 Jul 30;136(2):414-24. Unique Identifier : AIDSLINE
The simian sarcoma virus transformation-specific glycopeptide
(SSV-TrSgp) represents a proteoglycan which is released from
SSV-transformed cells and can be detected by an autologous goat serum
against SSV nonproducer cells (SSV-NP serum) (H.-J. Thiel, R.
Hafenrichter, and B. Gregor, 1984, Virology 134, 138-147). This
antiserum has now been shown to react also with human platelet-derived
growth factor (PDGF). Antiserum to PDGF precipitated a glycosylated
molecule from the tissue culture supernatant of SSV-NP cells. The
respective antigen was identified as the SSV-TrSgp (after
immunoprecipitation including enzymatic treatment with chondroitinases).
The anti-SSV-TrSgp reactivity of both the anti-PDGF serum and the SSV-NP
serum could be absorbed by pure PDGF. Therefore, the SSV-TrSgp is
apparently immunologically related to human PDGF. Additional studies
indicated that the SSV-TrSgp protein backbone and PDGF have very similar
Animal Carbohydrate Conformation Carbohydrate Sequence Cell Line
*Cell Transformation, Neoplastic Clone Cells Glycoside Hydrolases
Human Kidney Molecular Weight Platelet-Derived Growth
Factor/*ANALYSIS Rats Retroviridae/*GENETICS Sarcoma Viruses,
Simian/*GENETICS Structure-Activity Relationship Support, Non-U.S.
Gov't Viral Proteins/*ANALYSIS JOURNAL ARTICLE