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Progressive encephalopathy in children with acquired immune deficiency syndrome.


Ann Neurol. 1985 May;17(5):488-96. Unique Identifier : AIDSLINE

We are reporting the cases of four children with a diagnosis of acquired immune deficiency syndrome (AIDS) who demonstrated a progressive encephalopathy manifested by loss of motor milestones or intellectual abilities, and weakness with pyramidal tract signs. Two patients were ataxic. One child was cortically blind and suffered myoclonic jerks before his death. Two of the patients had isolated seizures at some time during the disease course. Two patients developed secondary microcephaly and all four patients showed cortical atrophy on computed tomographic scanning. Three of the patients died. Postmortem neuropathological findings included gross cortical atrophy, microglial nodules, and intranuclear inclusions, as are described in the subacute encephalitis reported in adult AIDS patients. We propose that the possible pathogenetic mechanisms of this encephalopathy include opportunistic or persistent viral infection of the brain.

Acquired Immunodeficiency Syndrome/*PATHOLOGY Atrophy Brain/PATHOLOGY/RADIOGRAPHY Brain Diseases/*PATHOLOGY/RADIOGRAPHY Case Report Child Child, Preschool Cytomegalovirus Infections/PATHOLOGY Electroencephalography Human Infant Male Myoclonus/COMPLICATIONS Seizures/COMPLICATIONS Tomography, X-Ray Computed JOURNAL ARTICLE


Information in this article was accurate in September 30, 1985. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.