glycosphingolipids of leukemic cells in adult t-cell leukemia-lymphoma.

NLM AIDSLINE Glycosphingolipids of leukemic cells in adult T-cell leukemia-lymphoma. Kuriyama M; Nomura K; Tara M; Matsubara H; Igata A
September 30, 1985

Biochim Biophys Acta. 1985 May 17;834(3):396-401. Unique Identifier : We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells and normal lymphocytes had monoglycosylceramide and diglycosylceramide as major neutral glycosphingolipids. In one patient, diglycosylceramide was markedly increased. II3NeuAc-LacCer (GM3) and more complex gangliosides were detected in both cells. The most characteristic finding in leukemic cells was the occurrence of a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal lymphocytes and neutrophils. This ganglioside may be due to the induced synthesis in association with malignant transformation. Cell Membrane/METABOLISM Chromatography, Thin Layer Gangliosides/METABOLISM Glycosphingolipids/METABOLISM Human HTLV-BLV Viruses Retroviridae Infections/METABOLISM T-Lymphocytes/*METABOLISM JOURNAL ARTICLE

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Information in this article was accurate in September 30, 1985. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.