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NLM AIDSLINE

Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.




 

Science. 1985 Jun 7;228(4704):1199-201. Unique Identifier : AIDSLINE

Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160, 120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-III-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS.

Acquired Immunodeficiency Syndrome/*VETERINARY Animal Antigens, Viral/ANALYSIS Glycoproteins/IMMUNOLOGY Lymphoma/MICROBIOLOGY Macaca/*MICROBIOLOGY Molecular Weight Monkey Diseases/MICROBIOLOGY Retroviridae/*IMMUNOLOGY/ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*MICROBIOLOGY Viral Proteins/IMMUNOLOGY JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1985. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.