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Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome.




 

Clin Immunol Immunopathol. 1985 Apr;35(1):43-6. Unique Identifier :

Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24/27 patients with Kaposi's sarcoma and in 2/15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Monoclonal/*IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Bacterial Infections/IMMUNOLOGY Human IgA/ANALYSIS IgG/ANALYSIS Immunoglobulins/*ANALYSIS Male Sarcoma, Kaposi's/IMMUNOLOGY JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1985. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.