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Symp Soc Gen Microbiol; 37:261-89 1985. Unique Identifier : AIDSLINE

The role of the human T-cell leukemia virus (HTLV) family in leukemia and immunosuppression and the mechanism of transformation, are discussed. Topics include growth of T-lymphoid cells, isolation and characterization of HTLV-1, epidemiology of HTLV-1 infection, clinical and pathological characteristics of adult T-cell leukemia-lymphoma (ATLL), monoclonality of HTLV-1-induced malignancies, transformation of lymphocytes by HTLV-1 in vitro, the role of T-cell growth factor (TCGF) receptors on HTLV-1-transformed lymphocytes, possible biological functions of the X region, cellular sequences activated in HTLV-transformed cells, HTLV-2, and subhuman primate homologues of HTLV (primate T-cell leukemia virus). HTLV-1 has many of the properties of a chronic leukemia virus, but can also transform T-cells, suggesting that HTLV-1 may accomplish transformation by a novel mechanism. Failure to demonstrate TCGF mRNA in HTLV-1-infected, TCGF-independent cell lines eliminates TCGF as playing a role in transformation, but still does not explain the presence of TCGF receptors on transformed cell lines. A comparison of the HTLV-1 and HTLV-2 genomes by Southern blotting analysis and heteroduplex mapping reveals a 1.O Kb sequence within the X region which appears to be one of the most conserved parts of the genome. Results suggest that a protein product of a long open reading frame within this region may mediate a biological property shared by the two viruses, such as T-cell tropism or transformation. The failure to find c-sis activation in all HTLV-transformed cells would argue that it plays a role in the transformation of some or perhaps no cell lines. However, the unique expression of c-sis in these hemopoietic cells suggests an important function for this gene product in this malignancy. HTLV-1 has a direct role in induction of ATLL, and may have a direct role in other diseases, including the B-cell chronic lymphocytic leukemia found in Jamaica. Viruses should be sought in T-cell malignant disorders such as mycosis fungoides, other non-malignant diseases involving T-cell abnormalities, and a wide range of other neoplastic and non-neoplastic conditions. (143 Refs)

Animal Antibodies, Viral/ANALYSIS Cell Transformation, Neoplastic/ANALYSIS Cell Transformation, Viral Cells, Cultured DNA, Viral/ANALYSIS *Genes, Viral Haplorhini Human HTLV-BLV Viruses/*GENETICS/IMMUNOLOGY/ISOLATION & PURIF Leukemia/ANALYSIS/*ETIOLOGY/GENETICS *Oncogenes Papio Receptors, Immunologic/ANALYSIS *Retroviridae Infections RNA, Viral/ANALYSIS T-Lymphocytes MEETING PAPER


Information in this article was accurate in October 30, 1986. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.