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Abnormal B-cell function in hemophiliacs treated with cryoprecipitate and factor VIII and IX concentrates.


Clin Immunol Immunopathol. 1986 Sep;40(3):447-55. Unique Identifier :

B-Cell function was evaluated in a group of 43 patients with factor VIII or factor IX deficiency. Thirty had been treated primarily with cryoprecipitate and 13 with concentrates of factor VIII or IX. Serum immunoglobulin G levels were found to be diffusely elevated; however, the absolute number of mature B cells in peripheral blood was normal. B-Cell function as measured by testing mitogen-induced proliferation and and immunoglobulin secretion by plaque-forming cells (PFC) in vitro was reduced. Coculture experiments suggested that these abnormal B-cell responses might be secondary to increased suppressor T-cell activity, which was found more frequently in patients seropositive for antibody to lymphadenopathy-associated virus. Both seronegative and seropositive patients had reduced responses in the proliferative and PFC assays, but the lowest PFC responses occurred in the seropositive group.

Adolescence Adult Aged B-Lymphocytes/*IMMUNOLOGY Child Christmas Disease/IMMUNOLOGY Factor IX/*THERAPEUTIC USE Factor VIII/*THERAPEUTIC USE Fibrinogen/*THERAPEUTIC USE Hemolytic Plaque Technique Hemophilia/DRUG THERAPY/*IMMUNOLOGY Human IgG/ANALYSIS Middle Age Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE


Information in this article was accurate in November 30, 1986. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.