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NLM AIDSLINE

Spastic paraparesis and HTLV-I infection in Peru.




 

Ann Neurol. 1988;23 Suppl:S151-5. Unique Identifier : AIDSLINE

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T-helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.

Adult Aged Antibodies, Viral/ANALYSIS/CEREBROSPINAL FLUID Blood Cells/PATHOLOGY Case Report Cell Division Female Human *HTLV-BLV Infections/CEREBROSPINAL FLUID/IMMUNOLOGY/PATHOLOGY Leukocytes, Mononuclear/PATHOLOGY Male Middle Age Muscle Spasticity/CEREBROSPINAL FLUID/ETIOLOGY/IMMUNOLOGY/ PATHOLOGY Myelitis/ETIOLOGY Paraplegia/CEREBROSPINAL FLUID/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY Peru Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE



 




Information in this article was accurate in June 30, 1988. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.