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NLM AIDSLINE

Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host.




 

Ann Neurol. 1988;23 Suppl:S108-12. Unique Identifier : AIDSLINE

The simian immunodeficiency virus (SIV) is closely related to the human immunodeficiency virus (HIV) in genomic organization and morphology. More important, SIV and HIV are both primate lentiviruses that cause transmissible immunodeficiency and encephalitis, with an apparently increased virulence in the immature host. The neuropathological features in common between SIV encephalitis in juvenile macaque monkeys and HIV encephalitis in children include the invasion of brain with virus-laden macrophages, the formation of multinucleated (syncytial) giant cells, and white matter lesions and subtle white matter astrocytosis. Important differences include giant cell leptomeningitis and evidence of necrosis and karyorrhexis in brain macrophage infiltrates in SIV-infected monkeys. These changes probably represent a more acute inflammatory process. The importance of future studies to define pathogenetic features of SIV encephalitis, using molecularly characterized isolates with varying neurovirulence and host range, are emphasized.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Animal Blood Vessels/PATHOLOGY Brain/PATHOLOGY/ULTRASTRUCTURE Cerebrovascular Circulation Comparative Study Encephalitis/ETIOLOGY/PATHOLOGY/*VETERINARY Human Infant Infant, Newborn *Macaca *Macaca mulatta Microscopy, Electron Monkey Diseases/*PATHOLOGY Opportunistic Infections/COMPLICATIONS Retroviridae Infections/COMPLICATIONS/*VETERINARY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE



 




Information in this article was accurate in June 30, 1988. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.