JAMA. 1988 Mar 25;259(12):1851-3. Unique Identifier : AIDSLINE
In an in vitro model, 20 condoms containing 0.9 mL of 6.6% (vol/vol)
nonoxynol 9 and ten condoms without nonoxynol 9 were tested as physical
and chemical barriers against human immunodeficiency virus (HIV). Each
condom was mounted on a hollow dildo and placed in a glass cylinder. The
HIV inoculum and HIV-free medium were placed on opposite sites of the
condom. Intercourse was simulated by pumping the dildo up and down in
the cylinder before and after deliberate rupture of the condom. Samples
for HIV culture were taken from outside and inside the condom, before
and after rupture. After rupture of nonoxynol 9-containing condoms, an
outside nonoxynol 9 concentration of 0.25% was reached. No condom
without nonoxynol 9 leaked HIV before rupture, but after rupture HIV
could be detected in medium outside of seven of ten condoms tested. In
none of 20 nonoxynol 9-containing condoms could HIV be detected in
outside medium after rupture. Thus, undamaged condoms provide an
effective physical barrier against HIV, and nonoxynol 9 may provide an
effective chemical barrier as well.
*Contraceptive Devices, Male *HIV/DRUG EFFECTS Models, Structural
Permeability Polyethylene Glycols/*PHARMACOLOGY Spermatocidal
Agents/*PHARMACOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE