Eur J Haematol. 1988 Jul;41(1):12-6. Unique Identifier : AIDSLINE
Granulomas in bone marrow are an infrequent finding related to diverse
disease. We reviewed 8057 bone marrow studies made over a period of 10.5
years, confirming the presence of granulomas in 40 patients. Global
incidence was 0.50% and annual incidence 3.80 cases/yr. Because of the
non-specificity of the morphological data, the diagnostic significance
of the finding is limited, but it does serve to narrow the field of
etiological possibilities. Associated disease was demonstrated in 82.5%,
infectious diseases being the most common (tuberculosis, brucellosis,
typhoid fever and kala-azar). Two previously unpublished entities are
introduced: refractory anemia with excess blast cells (dysmyelopoietic
syndrome) and malignant histiocytosis. 3 patients presented human
immunodeficiency virus infection, the etiopathogenic role of this
retrovirus in the generation of granulomas being unknown. The efficacy
of bone marrow study in demonstrating granulomas increases if both the
aspirate clot and bone cylinder are examined.
Acquired Immunodeficiency Syndrome/COMPLICATIONS Biopsy, Needle Bone
Marrow Diseases/ETIOLOGY/*PATHOLOGY Granuloma/ETIOLOGY/*PATHOLOGY
Hematologic Diseases/COMPLICATIONS Human Infection/COMPLICATIONS
Retrospective Studies Staining JOURNAL ARTICLE