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The spleen in acquired immunodeficiency syndrome (AIDS).


Pathol Res Pract. 1988 Aug;183(4):425-33. Unique Identifier : AIDSLINE

72 spleens from AIDS patients were studied by histologic and immunohistochemical methods. Apart from the opportunistic infections and malignancies typically occurring in AIDS patients (malignant lymphomas, Kaposi's sarcoma, mycobacterial infections, cryptococcosis, cytomegalovirus infections) morphological changes probably directly attributable to HIV infection were noted that progressed from follicular hyperplasia with nearly normal periarteriolar lymphoid sheaths to atrophy of follicles and severe cellular depletion of T cell areas with concomitant plasmacytosis and occurrence of small giant cells. At the same time the number of Protein S-100 positive cells markedly increased; in some cases almost all pulp cord macrophages expressed the antigen. In addition, the sinus endothelia strongly expressed protease inhibitors.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/DIAGNOSIS/ *PATHOLOGY Human Immunohistochemistry Opportunistic Infections/COMPLICATIONS Organ Weight Spleen/*PATHOLOGY JOURNAL ARTICLE


Information in this article was accurate in February 28, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.