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HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS.




 

J Acquir Immune Defic Syndr. 1988;1(1):13-7. Unique Identifier :

HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi's sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences in HLA-A or -B antigen frequencies were found in any comparisons of these groups. However, in comparisons of seropositive AIDS-free men with the AIDS groups, HLA-Cw7 was increased in frequency in OI and HLA-DR1, -DRw14, and -DQw1 in KS. HLA-DR3 and -DQw3 frequencies were decreased in KS, and DRw53 was decreased in OI. In a cohort of 102 HIV seropositive individuals that were followed for a mean of 43 months, AIDS developed in HLA-DR1 positive men more frequently than in individuals with other HLA-DR phenotypes (p = 0.02). These results demonstrate probable genetic differences between individuals developing KS and OI and indicate that the HLA-DR1 phenotype is a risk factor in disease progression in human immunodeficiency virus (HIV)-infected individuals.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY Human HIV Seropositivity/*IMMUNOLOGY *HIV-1 HLA Antigens/*ANALYSIS HLA-A Antigens/ANALYSIS HLA-B Antigens/ANALYSIS HLA-C Antigens/ANALYSIS HLA-DQ Antigens/ANALYSIS HLA-DR Antigens/ANALYSIS Male Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY Sarcoma, Kaposi's/ETIOLOGY/IMMUNOLOGY JOURNAL ARTICLE



 




Information in this article was accurate in May 30, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.