J Acquir Immune Defic Syndr. 1989;2(1):63-9. Unique Identifier :
CD4 and CD8 T lymphocytes of three groups of men infected by the human
immunodeficiency virus (HIV) were examined twice yearly for 36 months to
elucidate the temporal trends in T lymphocytes during infection. The
three groups were 37 HIV seroconverters, 304 prevalent HIV seropositives
remaining free of the acquired immunodeficiency syndrome (AIDS), and 69
men who developed AIDS during observation. Six months before
seroconversion, CD4 levels were similar among HIV seroconverters and 356
seronegative controls. Within 18 months of seroconversion, mean CD4
levels fell to the level of the prevalent seropositives at study entry.
From there, the rate of decline slowed. CD8 lymphocyte counts rose
dramatically at seroconversion. Among AIDS-free prevalent seropositives,
CD4 levels fell steadily over 36 months of observation. By contrast, CD8
cell levels rose slowly. Among men who developed AIDS, mean CD4 levels
fell more rapidly again during the 18 months prior to diagnosis. CD8
cell levels remained elevated until 6-12 months before diagnosis, when
they began to fall.
Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antigens,
Differentiation, T-Lymphocyte/ANALYSIS Cohort Studies Follow-Up
Studies Human HIV Seropositivity/*IMMUNOLOGY Male Support, U.S.
Gov't, P.H.S. T-Lymphocytes/*CLASSIFICATION/IMMUNOLOGY JOURNAL ARTICLE