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Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs.


Transfusion. 1989 Mar-Apr;29(3):265-7. Unique Identifier : AIDSLINE

In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected individuals is probably very low.

Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*PSYCHOLOGY/ TRANSMISSION Adult Female Hemophilia/COMPLICATIONS/*PSYCHOLOGY Human HIV Antibodies/ANALYSIS HIV Seropositivity/DIAGNOSIS/EPIDEMIOLOGY/*PSYCHOLOGY *HIV-1 Middle Age *Sexual Partners Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE


Information in this article was accurate in June 30, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.