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Implications from the occurrence of Reiter's syndrome and related disorders in association with advanced HIV infection.




 

Scand J Rheumatol Suppl. 1988;74:89-93. Unique Identifier : AIDSLINE

Information bearing on the prevalence and character of Reiter's syndrome and allied disorders as they occur in a setting of HIV infection was reviewed. Based on the frequency of infections by organisms capable of inducing reactive arthritis and the presence of HLA-B27 in 71% of the individuals, it was concluded that the disorder strongly resembled Reiter's syndrome occurring in the non-HIV infected group. Preliminary evidence suggested an enhanced penetrance of susceptibility among HLA-B27 individuals. In view of the preservation of CD8 lineage T cells and functional loss of CD4 lineage T cells in HIV-infected patients, it was suggested that a specific immune recognition event is at the center of the pathogenesis of this syndrome which involves preservation of an unknown antigen in the context of HLA-B27 to CD8 lineage suppressor/cytotoxic T cells.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY Arthritis/IMMUNOLOGY Disease Susceptibility Human HLA-B Antigens Psoriasis/IMMUNOLOGY Reiter's Disease/COMPLICATIONS/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE



 




Information in this article was accurate in June 30, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.