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Detection of human T-cell leukemia/lymphoma virus type I in a transfusion recipient with chronic myelopathy.


Neurology. 1989 Jun;39(6):841-4. Unique Identifier : AIDSLINE

A white man with a progressive spastic paraparesis that began 15 months after sustaining severe trauma in a motor vehicle accident was positive for antibodies to human T-lymphotropic virus type I (HTLV-I) by enzyme-linked immunosorbent assay. Serum antibody to HTLV-I was confirmed by Western blot and radioimmunoprecipitation assay. We detected specific proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction. Because the incidence of HTLV-I is generally restricted to Southern Japan and Caribbean black populations, the most likely source of HTLV-I infection in this patient was multiple intraoperative blood transfusions. The relatively short interval between transfusion and development of HTLV-I-associated myelopathy is consistent with the more rapid evolution of this clinical syndrome compared with adult T-cell leukemia.

Blood Transfusion/*ADVERSE EFFECTS Case Report Chronic Disease DNA, Viral/ANALYSIS Gene Amplification Human HTLV-I/*ANALYSIS Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/COMPLICATIONS/ DIAGNOSIS Male Middle Age Muscular Diseases/ETIOLOGY/*MICROBIOLOGY Serodiagnosis JOURNAL ARTICLE


Information in this article was accurate in September 30, 1989. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.