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[HIV infection in stage IV C-2 (CDC). Increase in the p24 antigen value before critical decrease in CD4+ lymphocytes]


Med Klin. 1989 Aug 15;84(8):369-72. Unique Identifier : AIDSLINE

The Center for Disease Control proposed a classification system of HIV-infection including a symptomatic stage IV C-2 with secondary infections like thrush, oral hairy leukoplakia and herpes zoster. Because the prognostic value of these symptoms for the development of AIDS has been proven and the CDC-classification does not include any immunological parameters we analyzed the numbers of CD4+-lymphocytes and the frequency of HIV-antigen in 65 HIV-infected individuals. When entering stage IV C-2, the incidence of HIV-antigenemia was as high as in full blown AIDS (53% and 60%, respectively). However, we observed no decrease of CD4+-lymphocytes as compared to earlier CDC-stages.--We conclude that in stage IV C-2 the increase of viral protein production proceeds independently from CD4+-status.

Antigens, CD4/*ANALYSIS Centers for Disease Control and Prevention (U.S.) CD4-Positive T-Lymphocytes/*IMMUNOLOGY English Abstract Gene Products, gag/*ANALYSIS Human HIV Infections/*CLASSIFICATION/IMMUNOLOGY Leukocyte Count United States Viral Core Proteins/*ANALYSIS JOURNAL ARTICLE


Information in this article was accurate in January 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.