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Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.


Biochem Biophys Res Commun. 1989 Oct 16;164(1):339-44. Unique Identifier

The potent protein kinase C inhibitors staurosporine, H-7, and UCN-01 were investigated for their effects on 12-0-tetradecanoylphorbol-13-acetate (TPA)--mediated CD4 down-regulation and on the augmentation of human immunodeficiency virus (HIV) expression. Staurosporine was the most effective TPA inhibitor for both of these actions. Because of its high cytotoxicity, the effect of H-7 on augmentation of HIV expression could not be determined. UCN-01 had no cytotoxic effect, but caused only little inhibition of the augmentation of HIV expression.

Alkaloids/PHARMACOLOGY Antigens, CD4/*IMMUNOLOGY Cell Line Comparative Study Down-Regulation (Physiology)/*IMMUNOLOGY Flow Cytometry Gene Products, gag/ANALYSIS Human HIV/*PHYSIOLOGY HIV Antigens/ANALYSIS Isoquinolines/PHARMACOLOGY Piperazines/PHARMACOLOGY Protein Kinase C/*ANTAGONISTS & INHIB Support, Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY Tetradecanoylphorbol Acetate/TOXICITY Viral Core Proteins/ANALYSIS Virus Replication JOURNAL ARTICLE


Information in this article was accurate in January 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.