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HIV-1 gp 41 antigen in the serum of HIV infected children.


Int Conf AIDS. 1989 Jun 4-9;5:496 (abstract no. B.592). Unique

OBJECTIVE: To detect the presence of HIV-1 gp 41 antigen in the sera of HIV-infected children and correlate with disease activity. METHODS: HIV-1 gp 41 antigen (Ag) was assayed by an immunoblot assay involving reaction with monoclonal gp 41 antibody followed by peroxidase-conjugated goat anti-mouse IgG. A positive reaction was detected by color development upon addition of substrate, and reactive samples visually graded from +1 to +4. One hundred forty-five samples from 100 patients were assayed. RESULTS: Eighteen of 100 (18%) patients had gp 41 Ag present in their sera. The concentration of gp 41 Ag increased in patients who had a severe clinical course and who died. The concentration of serum gp 41 paralleled the concentration of HIV proteins p17, p24 and gp 120 in the serum. CONCLUSION: The detection of gp 41 antigen can be of value as an additional marker of disease activity and prognosis and could be potentially useful in monitoring patients on treatment.

Antigens, Surface/*ANALYSIS Blotting, Western Child Human HIV Antigens/*ANALYSIS HIV Envelope Protein gp41/*IMMUNOLOGY HIV Infections/*DIAGNOSIS HIV-1/*IMMUNOLOGY Prognosis ABSTRACT


Information in this article was accurate in September 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.