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Natural history of AIDS in children of African origin seen in Belgium: evidence for two patterns.


Int Conf AIDS. 1989 Jun 4-9;5:319 (abstract no. T.B.P.197). Unique

OBJECTIVE: To describe the diseases indicative of AIDS in children of African origin seen in Belgium. METHODS: The children of African origin with at least one disease indicative of AIDS according to the latest CDC-case definition were selected. RESULTS: Forty-four children met the inclusion criteria (male/female ratio = 1). Three (7%) had a history of blood transfusion in Africa, the others were presumed to be born to an HIV infected mother. Following diseases indicative of AIDS were diagnosed: bacterial infections (n = 24), LIP/PLH complex (23), PCP (10), HIV encephalopathy (9), Candida albicans (5), herpes simplex (1), disseminated BCG (1), HIV wasting syndrome (1), HIV related cancers (1). Thirteen children (23%) are known to have died, 9/13 before the age of 12 months, all the others (4/13) after the age of 78 months. Thirty-one (77 %) were still alive when last seen (mean age 36 months, median 29 months, range 5-104 months). Twenty children (45 %) had only LIP/PLH complex and/or bacterial infections when last seen (mean age 48 months, median 44,5 months, range 8-103 months, mode 40-49 months), whereas 24 children (55 %) had true opportunistic infections and/or HIV encephalopathy and/or HIV related cancers when last seen (mean age 29 months, median 11.5 months, range 4-126 months, mode 0-9 months). CONCLUSIONS: Our data suggest that the natural history of HIV infection in African children is characterized by at least two patterns: one group of infants and younger children with rapid onset, a more severe expression of the disease and poor prognosis, and a second group of older children with later onset, a more chronic expression (only LIP/PLH complex and/or bacterial infections) but with potential poor prognosis after several years of evolution.

Acquired Immunodeficiency Syndrome/DIAGNOSIS/*EPIDEMIOLOGY Africa/ETHNOLOGY Belgium/EPIDEMIOLOGY Centers for Disease Control and Prevention (U.S.) Child Child, Preschool Female Human Infant Male Neoplasms/COMPLICATIONS/DIAGNOSIS Opportunistic Infections/COMPLICATIONS/DIAGNOSIS/MORTALITY Prognosis ABSTRACT


Information in this article was accurate in September 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.