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Are the pulmonary complications of AIDS changing?


Int Conf AIDS. 1990 Jun 20-23;6(3):189 (abstract no. S.B.413). Unique

OBJECTIVE: Non-specific interstitial pneumonitis (NSIP) has been reported to occur in 13-38% of AIDS patients. The present study was designed to ascertain: 1) whether the nature and incidence of pulmonary complications is changing; 2) does NSIP occur with the recently reported high frequency. METHODS: Between 3/88 and 12/89, 207 consecutive HIV+/AIDS patients who presented with fever, dyspnea and an abnormal chest x-ray underwent bronchoscopy with transbronchial biopsy and lavage (168) or sole lavage (39). RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. In addition, there were 2 cases of pulmonary lymphoma and 1 carcinoma. Ten patients (5%) had negative biopsies and/or lavage; CMV (6) or MTB (4) were found elsewhere and chest radiographs improved with therapy. There were 7 (4%) non-diagnostic bronchoscopies; all patients improved without therapy. Of the 31 patients with NSIP, 15 had previous pulmonary opportunistic infections or known pulmonary KS. Thus, only 16 (8%) had true NSIP without explicable causes. CONCLUSION: 1) PCP remains the most common pulmonary complication. 2) The relative incidence of pulmonary complications is similar to previous published reports. 3) In contrast to recent reports, NSIP does not occur with increasing frequency. When all known causes are excluded, it occurred in 8% of patients in the present study.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS/RADIOGRAPHY Human Incidence Lung Diseases/*COMPLICATIONS/RADIOGRAPHY Opportunistic Infections/COMPLICATIONS/RADIOGRAPHY Pneumonia, Pneumocystis carinii/RADIOGRAPHY Sarcoma, Kaposi's/ETIOLOGY/RADIOGRAPHY Thoracic Radiography ABSTRACT


Information in this article was accurate in December 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.