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Characterization of the HIV-specific cytotoxic T lymphocyte response in humans.


Int Conf AIDS. 1990 Jun 20-23;6(3):145 (abstract no. S.A.253). Unique

OBJECTIVE: To identify some of the HIV-infected cells that are targets to cytotoxic T lymphocyte attack in humans, and to determine the factors that control the intensity of the HIV-specific CTL response. METHODS: HIV-infected cells were collected by various procedures, including broncho-alveolar lavage. These cells were tested as targets to HIV specific, HLA restricted CTL. Various donors were used as a source of CTL, including HIV infected patients under AZT treatment, and seronegative individuals living in sexual contact with HIV-infected individuals. RESULTS: Various HIV-infected cells were shown to be good targets to HIV-specific CTL, including lung fibroblasts and macrophages, and CD4 T lymphoblasts. The specificities of these CTL reactions were defined with target cells transfected with cloned HIV genes. Follow-up of HIV-infected donors showed that AZT had an immuno-stimulatory effect at the beginning of treatment, but gradually dropped back to ground levels in most patients. The resistance to HIV infection detected in seronegative contacts could not be ascribed to an increased CTL response. CONCLUSION: The HIV-specific CTL response is effective in destroying a number of infected cells of divergent origins. This CTL response might be effective in prolonging survival of infected individuals, although our data are not indicative of protection by CTL against infection.

Bronchoalveolar Lavage Fluid/MICROBIOLOGY Cell Survival Human HIV/DRUG EFFECTS HIV Seropositivity/DRUG THERAPY/*IMMUNOLOGY Macrophages/DRUG EFFECTS/MICROBIOLOGY T-Lymphocytes, Cytotoxic/*IMMUNOLOGY/MICROBIOLOGY Transfection Zidovudine/PHARMACOLOGY ABSTRACT


Information in this article was accurate in December 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.