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HTLV-I associated neurological disorders in West Africa.


Int Conf AIDS. 1990 Jun 20-23;6(3):102 (abstract no. S.B.28). Unique

OBJECTIVE: The study aimed to evaluate seroprevalence of HTLV-I and associated disorders among neurological diseases in West Africa. METHODS: Between March and September 1987, 865 neurological ward in-patients were screened for HTLV-I, HIV-I and HIV-II using ELISA tests, confirmed by Western Blot. Patients came from 4 Black Africa countries: Ivory Coast (381), Senegal (216), Togo (129), and Burkina Faso (139). RESULTS: Positive cases were as follows: HTLV-I alone: 15 cases (1.7%), HIV-I and/or HIV-II associated with HTLV-I: 19 cases (2.2%), total HIV: 91 cases (11%), composed of 50 HIV-I alone (6%), 7 HIV-II alone (0.8%), 15 HIV-I and/or HIV-II (18%), and 19 HTLV-I associated cases (2.2%), Among the neurological disorders, 82 cases of spastic paraplegia were identified including PST/HAM. They were characterized by a markedly low prevalence of HTLV-I (13 cases, 15.85%) than other countries and by their association 7 out of 13 times with HIV-I/II (8.5%). Six cases of paraplegia with HTLV-I (HAP) presented similar clinical signs to those described elsewhere under the general term PST/HAM. Prevalence of HTLV-I alone for other disorders was identical to that found in a normal population (1-2%): 153 peripheral neuropathy patients: 3 cases (2%); 38 cranial nerve paralysis: 1 case (2.6%); 64 meningo-encephalitis: 1 case (1.6%); 129 non-tropical neuromyelopathic myelopathies: 2 cases (1.5%), and 399 other disorders: 2 cases (0.50%). A major etiological factor in meningo-encephalitis appears to be HIV-I/II (43.1%). CONCLUSION: Even though HTLV-I seroprevalence is raised in West Africa (approximately 2%), this retrovirus has a much reduced presence in neurological disorders. Its level in African spastic paraplegia is low.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/*EPIDEMIOLOGY Africa, Western/EPIDEMIOLOGY Human *HIV-1 *HIV-2 HTLV-I Infections/COMPLICATIONS/*EPIDEMIOLOGY Nervous System Diseases/*ETIOLOGY Paraplegia/ETIOLOGY Prevalence ABSTRACT


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