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NLM AIDSLINE

HTLV-I associated neurological disorders in West Africa.




 

Int Conf AIDS. 1990 Jun 20-23;6(3):102 (abstract no. S.B.28). Unique

OBJECTIVE: The study aimed to evaluate seroprevalence of HTLV-I and associated disorders among neurological diseases in West Africa. METHODS: Between March and September 1987, 865 neurological ward in-patients were screened for HTLV-I, HIV-I and HIV-II using ELISA tests, confirmed by Western Blot. Patients came from 4 Black Africa countries: Ivory Coast (381), Senegal (216), Togo (129), and Burkina Faso (139). RESULTS: Positive cases were as follows: HTLV-I alone: 15 cases (1.7%), HIV-I and/or HIV-II associated with HTLV-I: 19 cases (2.2%), total HIV: 91 cases (11%), composed of 50 HIV-I alone (6%), 7 HIV-II alone (0.8%), 15 HIV-I and/or HIV-II (18%), and 19 HTLV-I associated cases (2.2%), Among the neurological disorders, 82 cases of spastic paraplegia were identified including PST/HAM. They were characterized by a markedly low prevalence of HTLV-I (13 cases, 15.85%) than other countries and by their association 7 out of 13 times with HIV-I/II (8.5%). Six cases of paraplegia with HTLV-I (HAP) presented similar clinical signs to those described elsewhere under the general term PST/HAM. Prevalence of HTLV-I alone for other disorders was identical to that found in a normal population (1-2%): 153 peripheral neuropathy patients: 3 cases (2%); 38 cranial nerve paralysis: 1 case (2.6%); 64 meningo-encephalitis: 1 case (1.6%); 129 non-tropical neuromyelopathic myelopathies: 2 cases (1.5%), and 399 other disorders: 2 cases (0.50%). A major etiological factor in meningo-encephalitis appears to be HIV-I/II (43.1%). CONCLUSION: Even though HTLV-I seroprevalence is raised in West Africa (approximately 2%), this retrovirus has a much reduced presence in neurological disorders. Its level in African spastic paraplegia is low.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/*EPIDEMIOLOGY Africa, Western/EPIDEMIOLOGY Human *HIV-1 *HIV-2 HTLV-I Infections/COMPLICATIONS/*EPIDEMIOLOGY Nervous System Diseases/*ETIOLOGY Paraplegia/ETIOLOGY Prevalence ABSTRACT



 




Information in this article was accurate in December 30, 1990. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.