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Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.




 

Eur J Clin Microbiol Infect Dis. 1990 Aug;9(8):615-9. Unique Identifier

Phosphonoformate, ganciclovir, zidovudine and the novel acyclic nucleotide analogues (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were evaluated for their inhibitory effect on colony forming unit formation by human granulocyte-macrophage progenitor cells (obtained from 11 healthy volunteers) in vitro. The 50% inhibitory dose of zidovudine, (S)-HPMPA, (S)-HPMPC, ganciclovir and phosphonoformate were 10.61, 16.55, 80.88, 41.02 and 668.64 microM, respectively, when the median-effect principle was applied. The bone marrow toxicity of zidovudine used at a low concentration (3.74 microM) was significantly decreased if the drug was combined with (S)-HPMPA, (S)-HPMPC or ganciclovir. If used at higher concentrations (74.90 microM), zidovudine showed increased myelotoxicity in the presence of (S)-HPMPA and ganciclovir, but not (S)-HPMPC.

Adenine/ANALOGS & DERIVATIVES/PHARMACOLOGY Adult Antiviral Agents/*PHARMACOLOGY Bone Marrow/CYTOLOGY/DRUG EFFECTS Cells, Cultured Cytomegalovirus/*DRUG EFFECTS Cytosine/ANALOGS & DERIVATIVES/PHARMACOLOGY Ganciclovir/PHARMACOLOGY Granulocytes/DRUG EFFECTS Hematopoietic Stem Cells/*DRUG EFFECTS Human HIV/*DRUG EFFECTS Macrophages/DRUG EFFECTS Organophosphorus Compounds/PHARMACOLOGY Phosphonoacetic Acid/ANALOGS & DERIVATIVES/PHARMACOLOGY Support, Non-U.S. Gov't Zidovudine/PHARMACOLOGY JOURNAL ARTICLE



 




Information in this article was accurate in January 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.