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CD4+ monocyte counts in persons with HIV-1 infection: an early increase is followed by a progressive decline.


J Acquir Immune Defic Syndr. 1991;4(1):24-30. Unique Identifier :

In this study, we asked whether there is a difference in the number of CD4+ and CD4- peripheral blood monocytes as CD4+ T cells decrease during HIV-mediated immunodeficiency. Monocytes and T cells from 90 HIV-positive and 43 HIV-negative persons were analyzed by flow cytometry. The 90 HIV-positive patients represented the entire spectrum of CD4+ T-cell counts. We report that as CD4+ T cells decrease, the number of CD4+ monocytes decrease in parallel. Moreover, significantly higher CD4+ monocyte counts were observed in persons with early stage HIV disease, i.e., greater than 800 CD4+ T cells/mm3, than in HIV-negative persons with greater than 800 CD4+ T cells/mm3. Potential implications of these findings are discussed.

Analysis of Variance Antigens, CD4/*BLOOD Comparative Study CD4-Positive T-Lymphocytes/IMMUNOLOGY Flow Cytometry Human HIV Seropositivity/*BLOOD *HIV-1 Leukocyte Count Monocytes/*IMMUNOLOGY JOURNAL ARTICLE


Information in this article was accurate in March 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.