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Acid sensitivity of cell-free and cell-associated HIV-1: clinical implications.




 

AIDS Res Hum Retroviruses. 1990 Dec;6(12):1433-6. Unique Identifier :

Infectivity of free and cell-associated human immunodeficiency virus type 1 (HIV-1) treated in vitro at pH 7.4 to 4.9 for 2 hours was assessed on susceptible CEM-ss cells. Viral activity was monitored by cytopathology and production of reverse transcriptase and p24 antigen. The infectivity of cell-free virus was gradually inactivated and at pH 5.4 was completely lost, with or without subsequent adjustment of pH to neutral. Virus-producing cells also gradually lost their ability to infect as the pH decreased; however, restoration of neutral pH resulted in regained infectivity. Since the pH values used in the study are similar to those found at various entry sites of the human body, the data may be relevant to the mode of transmittal of HIV.

Cell Line Cell Survival Cell-Free System Human Hydrogen-Ion Concentration HIV-1/*PHYSIOLOGY Support, Non-U.S. Gov't *Virus Replication JOURNAL ARTICLE



 




Information in this article was accurate in July 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.