acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.

NLM AIDSLINE Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Thomson BJ; Efstathiou S; Honess RW; Division of Virology, National
August 30, 1991

Nature. 1991 May 2;351(6321):78-80. Unique Identifier : AIDSLINE Human herpesvirus type-6 (HHV-6) is a recently isolated herpesvirus which is highly prevalent in adult populations around the world. HHV-6 was first isolated from the peripheral blood of six individuals with lymphoproliferative disorders, two of whom were also infected with human immunodeficiency virus. HHV-6, in common with other herpesviruses, transactivates the HIV long terminal repeat linked to reporter genes and has in addition been shown to accelerate HIV gene expression and CD4 cell death in cultures co-infected with both viruses. The virus is tropic for CD4+ lymphocytes and persists in the peripheral blood of most seropositive individuals. We have now identified a gene in HHV-6 encoding a 490-amino-acid polypeptide homologous to the human adeno-associated virus type-2 (AAV-2) rep gene. This gene has an essential role in AAV-2 DNA replication, can trans-regulate homologous and heterologous gene expression, and inhibits cellular transformation. The acquisition of rep by HHV-6 could be due to natural transfer of genetic information between DNA viruses of eukaryotes and is likely to have important consequences for the life-cycle of HHV-6 and for the host CD4 cell. Amino Acid Sequence Base Sequence Comparative Study Dependovirus/GENETICS DNA Replication Genes, Viral Herpesvirus 6, Human/GENETICS Human Molecular Sequence Data Open Reading Frames Parvoviridae/GENETICS Restriction Mapping RNA, Messenger/GENETICS Sequence Homology, Nucleic Acid Support, Non-U.S. Gov't Transcription, Genetic TATA Box Viral Proteins/GENETICS JOURNAL ARTICLE

Most Read: Latest Added Related Topics White House LGBT Conference on HIV/AIDS UNITED STATES: White House in Atlanta: LGBT AIDS Conference No more single-theme conferences: global HIV prevention conference planned FHI 360 Senior Scientist Lut Van Damme Receives International Microbicide Conference Lifetime Achievement Award Equatorial Guinea Ministry of Health and Social Welfare and UNICEF Refute Erroneous AIDS Prevalence Figures Photographs from A Day with HIV Now Online Bulgaria urges Libya to investigate AIDS nurses case Engineers enter fight against AIDS in Africa Gilead’s Complera® Non-Inferior to Atripla® Among Treatment-Naive HIV Patients UN chief Ban calls world leaders to end Aids by 2020 COLORADO: Boulder Groups Honor More Than 150 Local AIDS Victims PENNSYLVANIA: Area Residents Screened for Hepatitis C on Sunday COLORADO: Peer to Peer: Teens Work to Educate Peers on Pregnancy, STDs at CCHS OREGON: Portland Barefoot 3 x 3 Benefit Tournament to Draw Hundreds to Northeast Portland TEXAS: Temple - Wellness and Sexual Health Classes Helping Kids to Abstain CONNECTICUT: Yale Researchers Urge More Street Work When Studying People With Both HIV, Hepatitis C JAMAICA: AIDS Awareness Workshop Organised for High-School Students EUROPE: EU Issues Stringent Sharps Regulations CALIFORNIA: $50,000 Prisoner Prescription: Inmates Get Expensive Hepatitis C Treatment Tentative approval of lamivudine and tenofovir disoproxil fumarate Tablets, 300 mg/300 mg Antiretroviral regimen associated with less virological failure among HIV-infected children NEW YORK: NY Rep.-- VA says 18 Vets Positive for Hepatitis 2012 US medicine sales show shifts by drug type NY Rep.: VA says 18 vets positive for hepatitis Metro TeenAIDS Honors Booz Allen Hamilton and Abt Associates With Founders Award for a Decade of Investment in DC Youth Study Results from Eunice Kennedy Shriver National Institute of Child Health and Human Development Provide New Insights into HIV/AIDS Monetising Human Waste and 101 (Slightly) Crazy Other Ideas Inhibikase Therapeutics to present at 5th International Congress on Polyomaviruses and Human Diseases - May 11, 2013 Grand Hotel Bristol, Stresa, Italy More than 60 dental patients test positive for viruses Honduras reforms its penal code to end human right violations based on sexual orientation and gender identity
Information in this article was accurate in August 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.